Gaucher disease is caused by deficiency of which enzyme?

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Multiple Choice

Gaucher disease is caused by deficiency of which enzyme?

Explanation:
Gaucher disease is caused by a deficiency of glucocerebrosidase, a lysosomal hydrolase (also called acid β-glucosidase). Without this enzyme, glucocerebroside cannot be broken down, so it accumulates in macrophages throughout the reticuloendothelial system, forming Gaucher cells that lead to organomegaly, bone pain, anemia, and thrombocytopenia. The other enzymes listed are linked to different storage diseases: sphingomyelinase deficiency with Niemann-Pick, hexosaminidase A deficiency with Tay-Sachs, and arylsulfatase A deficiency with Metachromatic leukodystrophy.

Gaucher disease is caused by a deficiency of glucocerebrosidase, a lysosomal hydrolase (also called acid β-glucosidase). Without this enzyme, glucocerebroside cannot be broken down, so it accumulates in macrophages throughout the reticuloendothelial system, forming Gaucher cells that lead to organomegaly, bone pain, anemia, and thrombocytopenia. The other enzymes listed are linked to different storage diseases: sphingomyelinase deficiency with Niemann-Pick, hexosaminidase A deficiency with Tay-Sachs, and arylsulfatase A deficiency with Metachromatic leukodystrophy.

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