Which autoantibody is commonly associated with scleroderma and is linked to interstitial lung disease and esophageal hypomotility?

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Multiple Choice

Which autoantibody is commonly associated with scleroderma and is linked to interstitial lung disease and esophageal hypomotility?

Explanation:
Autoantibody profiles help differentiate systemic sclerosis subsets and their typical organ involvement. Anti-centromere antibodies are most closely linked with limited cutaneous systemic sclerosis (CREST) and are commonly associated with esophageal hypomotility due to smooth muscle fibrosis in the distal esophagus, along with a potential but variable involvement of the lungs including interstitial changes. Other antibodies listed are more characteristic of different diseases (anti-dsDNA and anti-Smith with SLE, anti-RNP with MCTD) and do not align as well with the scleroderma pattern described. Thus, anti-centromere antibodies best fit the association with scleroderma features like esophageal hypomotility and interstitial lung involvement.

Autoantibody profiles help differentiate systemic sclerosis subsets and their typical organ involvement. Anti-centromere antibodies are most closely linked with limited cutaneous systemic sclerosis (CREST) and are commonly associated with esophageal hypomotility due to smooth muscle fibrosis in the distal esophagus, along with a potential but variable involvement of the lungs including interstitial changes. Other antibodies listed are more characteristic of different diseases (anti-dsDNA and anti-Smith with SLE, anti-RNP with MCTD) and do not align as well with the scleroderma pattern described. Thus, anti-centromere antibodies best fit the association with scleroderma features like esophageal hypomotility and interstitial lung involvement.

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